THE USE OF INTERIM DATA AND DATA MONITORING COMMITTEE RECOMMENDATIONS IN RANDOMIZED CONTROLLED TRIAL REPORTS: FREQUENCY, IMPLICATIONS AND POTENTIAL SOURCES OF BIAS

Abstract Background Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs).Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results.Metho

Interest in the development of stripper headers is growing owing to the excessive losses of combine harvesters and costs of manually harvesting for chickpeas.The design of a new concept can enhance the mechanized process for chickpea harvesting.A modified stripper platform Comb was designed, in which passive fingers with V-shape slots removes the p

The aim of Large Leg Desk the study is to evaluate the primary theoretical orientation of mental health workers (psychiatrist, psychologist, psychological counselor and social worker) in Turkey.The study was conducted with 133 psychiatrists, 312 psychologists, 430 psychological counselors and 198 social workers, a total 1073 (572 female, 501 male)

Color image authentication is a method that allows the detection of tampered regions on images.Existing related works evaluated their performance based on visual quality and detection capability of the marked image, but the issue of grayscale invariance was ignored.However, many applications in image processing required the color image to first con

Leontopithecus is the largest genus of Callithrichidae, occupying isolated remnants of the Atlantic Forest in Brazil.The objective of this study was to investigate the ultrastructure of the dorsum of the tongue of golden-headed lion tamarins.Tongues of ten adult lion tamarins kept in captivity at the Center of Primatology of Rio de Janeiro (CPRJ-FE